What is Torb Val syrup
Each mL of TORBUGESIC-SA contains 2 mg butorphanol base (as butorphanol tartrate); 3.3 mg citric acid; 6.4 mg sodium citrate; 4.7 mg sodium chloride; and 0.1 mg benzethonium chloride; q.s. with water for injection.
The magnitude and duration of analgesic activity of butorphanol were studied in cats under controlled laboratory conditions using both a visceral pain model and a somatic pain model.1,2 Subcutaneous butorphanol dosages of 0.4 mg / kg produced analgesia significantly (p <0.05) greater than the placebo for up to two hours in the somatic pain model. At the label dose (0.4 mg / kg), cardiopulmonary depressant effects were minimal after treatment with butorphanol as demonstrated in cats.1,2
Clinical studies confirmed the analgesic effect of butorphanol administered subcutaneously in the cat.
In field trials the overall analgesic effect was rated as satisfactory in approximately 75% of butorphanol treated cats. The duration of activity in cats responding to butorphanol ranged from 15 minutes to 8 hours. However, in 70% of responding cats the duration of activity was 3 to 6 hours following subcutaneous administration.
Safety Studies In Cats
Daily subcutaneous injections of butorphanol in cats, beginning at a dosage of 2 mg / kg the first week and doubling each week to a final dosage of 16 mg / kg on the fourth week, resulted in no deaths. No evidence of toxicity was observed during the first three weeks of the experiment, other than pain on injection. During the fourth week, transient incoordination, salivation, or mild seizures were observed within the first hour in the cats following the 16 mg / kg dosage (40 times the recommended clinical dosage). No other clinical, serum chemistry, or gross necropsy evidence of drug toxicity was encountered in any of the cats.
In subacute safety studies, butorphanol was injected subcutaneously to each of six cats at dosages of 0 (saline), 0.4, 1.2 or 2.0 mg / kg, every six hours for six days and continued once daily for a total of 21 days. The only adverse clinical effect observed was pain on injection. Histopathologic changes indicative of minimal to slight irritation were noted at the injection sites in 3 of 6 cats in the low dose group, 4 of 6 cats in the middle dose group and 6 of 6 cats in the high dose group. Histopathologic changes of focal renal tubular dilation were noted in half of the cats in the high dose group.
TORBUGESIC-SA (butorphanol tartrate injection) is indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
NOT FOR HUMAN USE.
TORBUGESIC-SA, a potent analgesic, should be used with caution with other sedative or analgesic drugs as these are likely to produce additive effects.
Safety for use in pregnant female cats, breeding male cats or kittens less than 4 months of age has not been determined. Use of TORBUGESIC-SA can therefore not be recommended in these groups.
In clinical trials in cats, pain on injection, mydriasis, disorientation, swallowing / licking and sedation were reported.
The recommended dosage in cats is 0.4 mg of butorphanol per kilogram body weight (0.2 mg / lb) given by subcutaneous injection. This is equivalent to 1.0 mL of TORBUGESIC-SA per 10 lbs of body weight.
Pre-clinical model studies and clinical field trials in cats demonstrated that the analgesic effects of TORBUGESIC-SA are seen within 20 minutes and persist in the majority of responding cats for 3 to 6 hours following subcutaneous injection (see Feline Pharmacology). The dose may be repeated up to 4 times per day for up to 2 days.
Use contents within 4 months of first puncture.
10 mL vials TORBUGESIC-SA (butorphanol tartrate injection) Veterinary Injection, 2 mg base activity per mL.
10 mL - vials
Store at controlled room temperature 20 ° -25 ° C (68 ° -77 ° F) with excursions between 15 ° -30 ° C (59 ° -86 ° F).
1. Sawyer, D.C. and Rech, R.H. "Analgesia and Behavioral Effects of Butorphanol, Nalbuphine and Pentazocine in the Cat," J. Amer. Hosp. Assoc. 23: 438-446, 1987.
2. Mandsager, R.E. and Raffe, M.R. "Evaluation of Periosteal Nociception in the Cat," PVN 2 (4): 237-242, 1991.
Approved by FDA under NADA # 141-047
Manufactured by: Zoetis Manufacturing and Research Spain, S.L., Olot, Spain
Distributed by: Zoetis Inc., Kalamazoo, MI 49007
Revised: July 2019
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